"Fat soluble" mono and dithiols have been found to prevent the lysis of erythrocytes by arsine in vitro when they are added five minutes after the cells have been exposed to arsine. Be sure to have them regularly checked by a professional. Medical Management Guidelines for Arsine. 43(5):353-5. Consider using bronchodilators in patients with bronchospasm or racemic epinephrine aerosol in children with wheezing. Click here for information on individual ASPET membership, ARSINE POISONING, MODE OF ACTION AND TREATMENT. Arsine poisoning symptoms, causes, diagnosis, and treatment information for Arsine poisoning (Chemical poisoning - Arsine) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis. [Medline]. Song Y, Wang D, Li H, Hao F, Ma J, Xia Y. [18]. [Medline]. Circulation: Treat hypotension with normal saline (NS) or lactated Ringer solution. Click here for information on institutional subscriptions. • Inhalation exposures: The signs and symptoms of acute poisoning are consistent with acute and massive hemolysis. Arsine gas poisoning: the importance of exchange transfusions in severe cases. Victims who have exposure only to arsine gas do not need decontamination. Liver function tests indicated all sero-floccula tion tests to be abnormal. Patients occupationally over exposed to arsenic may want to discuss with employers their concerns regarding ways to prevent this hazardous exposure. 1975 Sep 6. This should be done in consultation with a clinical expert in arsenic poisoning treatment. Severe acute arsine poisoning treated by plasma exchange. Chemical poisoning -- Arsine: Arsine is a chemical used in the making of semiconductors and in the metal refining industry. for: Medscape. Dry with clean towels and keep victim warm and quiet. [Medline]. A thorough eye examination should be performed along with an ophthalmologist consultation if needed in patients with eye injuries. Arsine or Stibine Poisoning. Arsine poisoning. Kermit D Huebner, MD, FACEP is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, Association of Military Surgeons of the US, Society for Academic Emergency Medicine, Society of United States Air Force Flight SurgeonsDisclosure: Nothing to disclose. Cases of poisoning, some of them fatal, have followed the accidental wettingof suchwastematerial. 5. poisoning. Chemical protective clothing is usually not required since arsine gas is not directly absorbed through the skin. the L.D.100. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODMzNzQwLXRyZWF0bWVudA==. The prognosis of Naphthalene Poisoning is dependent on the amount of substance consumed, time between exposure and treatment, severity of the symptoms, as well as general health status of the patient If the individual can recover from the symptoms, with appropriate medication and prompt medical support, the outcome can be good. Rescuers must be appropriately trained and attired before entering the hot zone. Request PDF | Treatment for acute arsine poisoning with blood purification | Dear Editor,Accidental exposure to arsine (AsH3) can lead to intravascular hemolysis, multiorgan damage, and death [1, 2]. Chronic poisoning has a better outcome. Bjørklund G, Mutter J, Aaseth J. • Inhalation exposures: The signs and symptoms of acute poisoning are consistent with acute and massive hemolysis. Hesdorffer CS, Milne FJ, Terblanche J, Meyers AM. Treatment is symptomatic and consists of measures to support respiratory, vascular, and renal function. [Medline]. Certain dithiols will protect tissue respiration from inhibition by arsine and arsenite. Arsine poisoning treated by plasma exchangeYUGUO SONG, M.D. Available at http://emergency.cdc.gov/agent/arsine/casedef.asp. Danielson C, Houseworth J, Skipworth E, Smith D, McCarthy L, Nanagas K. Arsine toxicity treated with red blood cell and plasma exchanges. Because of the possible danger of central nervous system damage caused by the injection of this compound into a vein, the percutaneous route of administration is to be preferred. Diseases & Conditions, encoded search term (Arsine Poisoning) and Arsine Poisoning, Anemia of Chronic Disease and Kidney Failure, Online Misinformation Fuels a FightOver Folic Acid, Higher Red-Cell Transfusion Limit for Preemies Offers No Survival, Developmental Benefit, Top 10 Gastroenterology Articles Provide Essential Guidance, Hidden Diagnoses: From Einstein to Luther, JFK to Evita, Don't Use N95 Masks for More Than 2 Days, Research Suggests, A 30-Year-Old Man With Hallucinations After a House Party, Lower Back Pain: NSAID + Muscle Relaxant No Better Than NSAID + Placebo, Add Delirium to Checklist of COVID-19 Symptoms in Seniors. Arsine poisoning treatment should focus on restoring RBC concentrations, maintaining renal function, electrolyte replacement and aggressive supportive care. In the event of acute arsine exposure in a pregnant patient, maternal toxicity is likely to be a major determinant of risk to the fetus. Exchange transfusions lower blood arsenic levels, but … April 4, 2018; Accessed: February 16, 2019. Initially, there is painless hemoglobinuria, dizziness, weakness, nausea, vomiting, abdominal cramping and tenderness. If hemolysis is present, the patient/victim must be observed up to 72 hours for signs of renal failure. It is considered a possible chemical agent in chemical warfare. Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics, You may purchase access to this article. Progress and treatment Liver function The jaundice faded rapidly. Chemical poisoning -- Arsine: Arsine is a chemical used in the making of semiconductors and in the metal refining industry. According to the Agency for Toxic Substances and Disease Registry, the following are recommendations for prehospital care of arsenic exposure. Duane C Caneva, MD, MSc Senior Medical Advisor to Customs and Border Protection, Department of Homeland Security (DHS) Office of Health Affairs; Federal Co-Chair, Health, Medical, Responder Safety Subgroup, Interagency Board (IAB)Disclosure: Nothing to disclose. The limited efficacy of conventional drug therapy prompted us to investigate the application of hybrid blood purification treatment (HBPT) to improve the prognosis in … The treatment depends on the type and stage of the arsenic poisoning. 55(2):468-77. Treatment: There is no specific antidote for arsine. J Natl Med Assoc. Make sure your boat is naturally ventilated. Apoptosis. Contact the blood bank and hematologist regarding exchange transfusion. In cases of contact with liquid (compressed gas), gently wash frosted skin with water; gently remove clothing from affected area. Arsine, the most toxic form of arsenic, has some properties that may make it useful as a chemical warfare (CW) agent; it is a colorless, odorless, nonirritating gas that is 2.5 times denser than air. Emergency Preparedness and Response. Consider dopamine for hypotension or oliguria. Centers for Disease Control and Prevention. Hypotension should be addressed with infusion of normal saline or lactated Ringer solution. Paresthesias and peripheral neuropathy are common symptoms of a work-related arsenic poisoning. Environ Toxicol Pharmacol. [25] How to reduce the risk of carbon monoxide poisoning on a boat. [Medline]. Initially, there is painless hemoglobinuria, dizziness, weakness, nausea, vomiting, abdominal cramping and tenderness. • Dermal exposures:An abnormal pigmentation of the skin may be seen. Toxicol Sci. Treatment. Initially, there is painless hemoglobinuria, dizziness, weakness, nausea, vomiting, abdominal cramping and tenderness. Ocular exposures: Red staining of the conjunctiva may be an early sign of arsine poisoning. 2,3-dimercaptopropyl ethyl ether has been shown to be effective in the treatment of arsine poisoning in rabbits, monkeys and dogs when administered either intramuscularly or percutaneously. There are no published guidelines specific to the treatment of arsine poisoning during pregnancy. The most important side effect is … 3. 1990 Jul. Whole blood exchange transfusion and hemodialysis have been recommended to treat severe acute arsine poisoning, but are associated with significant complications and sub-optimal outcomes. [Medline]. The victim is transported to a medical facility as soon as possible. 5. [Full Text]. If you log out, you will be required to enter your username and password the next time you visit. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. Renal damage from industrial arsine poisoning. 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